#036 Judith Campisi, Ph.D. on Cellular Senescence, Mitochondrial Dysfunction, Cancer & Aging

Dr. Judith Campisi is a professor of biogerentology at the Buck Institute for Research on Aging and a co-editor in chief of the Aging Journal.

As an expert on cellular senescence, the discussion involves a lot of talk about aging and cancer, where senescence plays a very important fundamental role. What are some of the strategies we might use in the future to prevent senescent cells? What causes them in the first place? 

In this episode, you’ll discover: 

• (00:00) Introduction
• (05:12) Fundamental molecular and cellular processes of aging
• (13:19) What is senescence and why did we evolve this cellular function? 
• (24:09) The difference between lifespan and healthspan
• (30:32) DNA damage and mitochondrial dysfunction promote senescence 
• (35:45) Prolonged fasting suppresses senescent cells and stimulates new cell growth
• (47:30) Exercise extends healthspan, partially by lengthening telomeres
• (54:03) Consumer tests for DNA damage and cellular senescence
• (59:58) NAD+ boosters, fasting mimetics, and aging in non-human animals

If you’re interested in learning more, you can read the full show notes here.

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