#038 Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation

Dr. Guido Kroemer

Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy.

He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death.

In this episode, you’ll discover: 

• (00:00) Introduction
• (09:09) The three main nutrient signals that activate autophagy
• (20:55) The role of fasting and nutrient deprivation in autophagy
• (28:52) Exercise induces autography 
• (33:07) Autophagy cleans out damaged organelles
• (35:14) Mitophagy keeps mitochondria healthy
• (39:38) Autophagy clears away neurodegenerative proteins in the brain
• (48:29) Autophagy in cancer is a double-edged sword
• (54:52) Fasting mimetics (e.g., resveratrol, spermidine, hydroxycitrate) induce autophagy

If you’re interested in learning more, you can read the full show notes here.

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